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Major depression frequently occurs with other types of psychiatric problems.

The co-occurrence of one or more disorders is called comorbidity, which is formally defined as the presence of a disorder(s) in addition to the diagnosis of a primary disease or disorder.

Anxiety symptoms can have an impact upon a depressive illness.

Delayed recovery, increased risk of relapse, and increased attempts of suicide all contribute to the increase of anxiety symptoms, and the increased rates of alcohol and drug abuse.

For example, post-traumatic stress disorder and depression tend to co-occur.

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